| Product Name | Mouse anti-FLI-1, clone MRQ-1 (Monoclonal) |
|---|---|
| Description | Mouse anti-FLI-1, clone MRQ-1 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MRQ-1 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG2b |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:25-1:100) |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | Friend leukemia integration 1 transcription factor (FLI-1) is a protein encoded by the proto-ocogene FLI1. The FLI-1 protein is best known for its critical role in the pathogenesis of ES/pPNET. FLI-1 is normally expressed in endothelial cells and in hematopoietic cells, including T-lymphocytes. The immunohistochemical detection of FLI-1 protein has been shown in studies to be valuable in the discrimination of Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/pPNET) from most of its potential mimics. ES/pPNET is a rare primary tumor of the bone/soft tissue that resembles other undifferentiated tumors. |
| References | Mhawech-Fauceglia P, et al. Histopathology. 2006; 49:569-75. Kuroda N, et al. Med Mol Morphol. 2006; 39:221-5. Ellison DA, et al. Hum Pathol. 2007; 38:205-11. Blind C. et al. . J Clin Pathol. 2008 Jan;61(1):79-83. Epub 2007 Apr 5 |
| Supplier | MONOSAN |
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