| Product Name | Mouse anti-Geminin, clone EM6 (monoclonal) |
|---|---|
| Description | Mouse anti-Geminin, clone EM6 (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | EM6 |
| Immunogen | A prokaryotic recombinant protein containing amino acids 5–209 of the mature protein. |
| Isotype | IgG2a |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:40) |
| Diluent Buffer | Tissue culture supernatant with 15mM Sodium azide |
| Concentration | Greater than or equal to 19 mg/L |
| Storage | 2-8°C |
| Notes | Geminin is a protein of 209 amino acids thought to be involved in the control of DNA replication via the interaction with Cdt1. Geminin is not found in the G1 phase of the cell cycle, but is first expressed in the G1 to S transition phase, with expression levels rising through the rest of the cell cycle and levels reaching a maximum during mitosis. It has been proposed that geminin may be a tumor suppressor protein. Geminin is reported to be expressed in proliferating lymphocytes and epithelial cells, for example, germinal centers in tonsil as well as in colon, spermatocytes, seminiferous tubules of the testes, within the basal layers of the squamous epithelium of the skin and breast. Geminin is reported to be upregulated in cancers such as non-Hodgkin's lymphoma, B cell lymphoma, breast carcinoma and colon carcinoma. |
| References | McGarry TJ and Kirschner MW. Cell. 1998; 93:1043–1053 |
| Supplier | MONOSAN |
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