| Product Name | Mouse anti-Granzyme A, clone GA6 (Monoclonal) |
|---|---|
| Description | Mouse anti-Granzyme A, clone GA6 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | GA6 |
| Immunogen | Recombinant human Granzyme A. |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC-P, WB |
| Working Dilutions | , |
| Diluent Buffer | PBS with 0.09% sodium azide |
| Concentration | 1.0 mg/ml |
| Storage | 2-8°C |
| Notes | Mouse anti Human granzyme A antibody, clone GA6 recognizes Granzyme A, a ~60 kDa disulphide-linked homodimeric protein of two 262 amino acid chains, expressed in cytoplasmic granules of cytotoxic lymphocytes and NK cells.Granzyme A is involved in the induction of apoptosis via its activity as a serine protease, but this would seem to be subsidiary to the role of Granzyme B. Granzyme A deficient mice are indistinguishable from normal animals in their response to infection.Granzyme A has been proposed as a potential biomarker for patients with active tuberculosis with significantly lower levels present in the plasma of patients with the active form of the disease compared to patients with latent infection (Guggino et al. 2015). |
| References | Kummer, J. A. et al. (1993) Production and characterisation of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins. J. Immunol. Methods. 163: 73-83 |
| Supplier | MONOSAN |
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