| Product Name | Mouse anti-HHV-8, clone 13B10 (Monoclonal) |
|---|---|
| Description | Mouse anti-HHV-8, clone 13B10 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 13B10 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:50-1:200) |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | Human herpesvirus type 8 (HHV-8) is the likely etiological agent of Kaposi's sarcoma (KS). HHV-8 DNA sequences have been found in Kaposi's sarcoma lesions, primary effusion lymphoma, and multicentric Castleman's disease via polymerase chain reaction and in situ hybridization. Latent nuclear antigen (LNA1, LNA, LANA-1), also known as ORF73, is a 222- or 234 kD protein that is consistently expressed in HHV8 infected cells. Anti-HHV-8 labels the latent nuclear antigen protein via immunohistochemistry |
| References | Corbellino M et al AIDS Res Hum Retroviruses.;12(8):651-7 (1996). Schwartz EJ et al. Am J Surg Pathol.;27(12):1546-50 (2003). Boulanger E et al. Am J Hematol.;76(1):88-91 (2004). Courville P et al. Ann Pathol.;22(4):267-76 (2002). Hong A et al. Pathology.;35(5):448-50 (2003) |
| Supplier | MONOSAN |
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