| Product Name | Mouse anti-HLA-E, clone MEM-E/02 (Monoclonal) |
|---|---|
| Description | Mouse anti-HLA-E, clone MEM-E/02 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MEM-E/02 |
| Immunogen | Recombinant human HLA-E denaturated heavy chain. |
| Isotype | IgG1 |
| Reactivity | Human, Primate |
| Applications | IHC-P, WB |
| Working Dilutions | , |
| Diluent Buffer | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Concentration | 1 mg/ml |
| Storage | 2-8°C |
| Notes | HLA-E (human leukocyte antigen E) is a non-classical MHC I antigen, which is important for dialogue with NK cells and their regulation through interaction with CD94/NKG2 receptor. Like other MHC I molecules, transmembrane HLA-E molecule (45 kDa) associates with beta2 microglobulin. Unlike HLA-G, expression of HLA-E molecules is not so restricted, but it has been detected at least at mRNA level in virtually all cells and tissues examined. In peripheral blood, HLA-E protein is expressed at least in all mononuclear cells, but in different quantity (B cells and monocytes more than T cells and NK cells). |
| References | Menier C. et al., Hum. Immunol. 64, 315 (2003) |
| Supplier | MONOSAN |
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