| Product Name | Mouse anti-Human p21, clone DCS-60.2 |
|---|---|
| Description | Mouse anti-Human p21, clone DCS-60.2 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | DCS-60.2 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG1-k |
| Reactivity | Human |
| Applications | IHC-P |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | p21 is one of the inhibitors of the phosphorylation of the cyclin-cdk complex. p21, which is an inhibitor of G1 cdks, suppresses the cell cycle and inhibits DNA synthesis. Although p21 is induced by p53 and inhibits cdk (cyclin-dependent kinase) activity, there was virtually no correlation between the expression of p21 and that of p53; this finding was consistent with two reports, though another reported an inverse correlation between the expression of p21 and that of p53. p53-independent expression of p21 might account for the discrepancy between the expression of p53 and that of p21. It is expressed in normal human tissue and a wide array of tumors. |
| References | El-Ghobashy AA, et al. Eur J Cancer. 2007 Sep;43(13):2011-8. Epub 2007. Fillies T, et al. Oncol Rep. 2007 Feb;17(2):355-9. DiGiuseppe JA, et al. Am J Pathol. 1995; 147:884-8. Xie HL, et al. World J Gastroenterol. 2004; 10(8):1125-31. Stein JP, et al. J of Natl Cancer Inst. 1998; 90:1072-8 |
| Supplier | MONOSAN |
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