| Product Name | Mouse anti-Human p53, clone DO7 (Monoclonal) |
|---|---|
| Description | Mouse anti-Human p53, clone DO7 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | DO7 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG2b-k |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:100-1:500) |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes |
The antibody recognizes a 53 kDa phosphoprotein, identified as p53 suppressor gene product. It reacts with the mutant as well as wild type p53.1 Positive nuclear staining with this antibody has been shown to be a factor in breast carcinoma, lung carcinoma, colorectal carcinoma, urothelial carcinoma, and ependymoma.2-8 Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma, as well as a marker for intratubular germ cell neoplasia. |
| References | Mauri FA et al. Int J Oncol 1999 Dec;15(6):1137-47. Caffo O et al. Clin Cancer Res 1996 Sep;2(9):1591-9. Bebenek M et al. Anticancer Res 1998 Jan-Feb;18(1B):619-23. Midulla C et al. Anticancer Res 1999 Sep-Oct;19(5B):4033-7. Moore BE et al. App.IHC and Mol. Morphol. 2001;9(3): 203 –206 |
| Supplier | MONOSAN |
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