| Product Name | Mouse anti-Human TCL1, clone MRQ-7 (Monoclonal) |
|---|---|
| Description | Mouse anti-Human TCL1, clone MRQ-7 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MRQ-7 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:100-1:500) |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | T-cell leukemia/lymphoma protein 1 (TCL1, TCL1A, p14TCL1) is a 14 kDa product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (T-PLL). TCL1 protein is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. TCL1 is expressed in differentiated Bcells under both reactive and neoplastic conditions, antigen committed B-cells, and in germinal center B-cells. The Anti-TCL1 immunohistochemical reactivity is reportedly useful identifying B-cell lymphomas including follicular lymphoma and Burkitt lymphoma. |
| References | Takizawa J, et al. Jpn J Cancer Res. 1998; 89:712-8. Narducci MG, et al. Cancer Res. 2000; 60:2095-100. Rodig SJ, et al. Am J Surg Pathol. 2008; 32:113-22. Herling M, et al. Leukemia. 2006; 20:280-5. Pescarmona E, et al. Histopathology. 2006; 49:343-8 |
| Supplier | MONOSAN |
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