| Product Name | Mouse anti-Human IgG4, clone MRQ-44 (Monoclonal) |
|---|---|
| Description | Mouse anti-Human IgG4, clone MRQ-44 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MRQ-44 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG1-k |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:100-1:500) |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. Clinical manifestations are apparent in the pancreas, bile duct, gall bladder, lacrimal gland, salivary gland, retroperitoneum, kidney, lung, breast, thyroid, and prostate. Immunohistochemical analyses in the case of IgG4-related sclerosing disease not only exhibit significantly more than normal IgG4-positive plasma cells in affected tissues but also significantly higher IgG4/IgG ratios (typically > 30%). |
| References | Sakata N, et al., Am J Surg Pathol. 2008; 32:553-9. Dhobale S, et al., J Clin Rheumatol. 2009; 15:354-7. Li Y, et al., Pathol Int. 2009; 59:636-41. Koyabu M et al., J Gastroenterol. 2010; 45:732-41. Kamisawa T, et al., World J Gastroenterol. 2009; 21:2357-60 |
| Supplier | MONOSAN |
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