| Product Name | Mouse anti-IL-1 RII, clone 6G5 (Monoclonal) |
|---|---|
| Description | Mouse anti-IL-1 RII, clone 6G5 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 6G5 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG2a |
| Reactivity | Human |
| Applications | ELISA |
| Diluent Buffer | PBS with 0.1% BSA and 0.02% sodium azide |
| Concentration | 100 ug/ ml |
| Storage | 2-8°C |
| Notes | The antibody reacts specificly with Human IL-1RII. The IL-1 system includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1RI and IL-1RII) and the IL-1 receptor accessory protein. The IL-1RII is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signaling molecule which functions by capturing IL-1 and preventing it from interacting with the signalling IL-1RI. The decoy IL-1RII can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by coreceptor competition. Further a soluble form of IL-1RII exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes, polymorphonuclear cells, B cells and fibroblasts. |
| References | Mantovani; A et al. Ann N Y Acad Sci 1998; 840: 338. Penton-Rol, G et al J Immunol 1999, 162: 2931. Muller; B et al. J Leukoc Biol 2002; 72: 643 |
| Supplier | MONOSAN |
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