| Product Name | Mouse anti-IP-10, clone 6D4 (Monoclonal) |
|---|---|
| Description | Mouse anti-IP-10, clone 6D4 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 6D4 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG2a |
| Reactivity | Human |
| Applications | IHC-Fr, ELISA, FC, IF, WB |
| Working Dilutions | ,,,, |
| Diluent Buffer | PBS with 0.1% BSA and 0.02% sodium azide |
| Concentration | 100 ug/ ml |
| Storage | 2-8°C |
| Notes | The monoclonal antibody 6D4 recognizes human C-X-C motif chemokine 10 (IP-10), a protein of 98 amino acids. IP-10, also known as CXCL10, functions as ligand for the CXCR3 receptor. IP-10 belongs to the α-chemokine (C-X-C) family, which can be divided in two subfamilies: (1) potent chemoattractants for neutrophils, like IL-8 and (2) potent chemoattractants for lymphocytes, like the IFNÉ£ inducible protein (IP)-10. IP-10 is produced by a wide variety of cell types ranging from neutrophils, dendritic cells and monocytes to hepatocytes, endothelial cells and keratinocytes. The cytokine is reported to be involved in a scala of inflammatory pathologies such as HIV, encephalitis, cutaneous T cell lymphoma, chronic hepatitis, psoriasis and acute anterior uveitis. Various observations strongly suggest a role for the C-X-C chemokines IL-8 and IP-10 in the regulation of angiogenic activity in cancer and in idiopathic pulmonary fibrosis. Furthermore IP-10 is associated with acute rejection processes estimated by the predictive properties of urinary IP-10 expression for the short- and long-term graft function after kidney transplantation. |
| References | Hamamdzic; D Am J Physiol Lung Cell Mol Physiol 2001; 280: L18. Giustizieri, M et al Am J Path 2002, 161: 1409. Bendriss-Vermare; N et al. J of Leukoc Biol 2005; 78: 954. Curbishley S et al. Am J Pathol 2005; 167: 887. Wetzel M et al. J Immunol 2000; 165: 6519 |
| Supplier | MONOSAN |
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