| Product Name | Mouse anti-Kappa Light Chains, clone L1C1 |
|---|---|
| Description | Mouse anti-Kappa Light Chains, clone L1C1 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | L1C1 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG1-k |
| Reactivity | Human |
| Applications | IHC-P |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes |
The antibody detects surface immunoglobulin on normal and neoplastic B-cells. In paraffin-embedded tissue, anti-kappa exhibits strong staining of kappa-positive plasma cells and cells that have absorbed exogenous immunoglobulins. When dealing with B-cell neoplasms, the determination of light chain ratios remains the centerpiece. Most B-cell lymphomas express either kappa or lambda light chains, whereas reactive proliferations display a mixture of kappa and lambda positive cells. If only a single light chain type is detected, a lymphoproliferative disorder exists. Monoclonality is determined by a kappa-lambda ratio of greater than or equal to 3:1 or a lambda-kappa ratio greater than 2:1. |
| References | Hertel, BF, et al. Lab Invest 1977;36:12. Mendes S, Dreno B. Acta Derm Venereol. 2003;83(3):167-70. Lee LA et al. Am J Otolaryngol. 2002 Sep-Oct;23(5):316-20. Taylor, CL Arch Pathol Lab Med 1978;12:113-121. Schmid U et al. Am J Surg Pathol. 1995 Jan;19(1):12-20 |
| Supplier | MONOSAN |
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