| Product Name | Mouse anti-LTA, clone 55 (Monoclonal) |
|---|---|
| Description | Mouse anti-LTA, clone 55 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 55 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG3 |
| Applications | IHC-Fr, ELISA, FC, IF, WB |
| Working Dilutions | ,,,, |
| Diluent Buffer | PBS with 0.1% BSA and 0.02% sodium azide |
| Concentration | > 200 ug/ ml |
| Storage | 2-8°C |
| Notes | The monoclonal antibody 55 recognizes lipoteichoic acid (LTA). LTA, a glycerol phosphate surface polymer, is a component of the envelope of Gram-positive bacteria. LTA is anchored via its glycolipids to the membrane and carries a polysaccharide chain extending into the peptidoglycan layer of the cell wall. LTA is released spontaneously into the culture medium during growth of gram-positive bacteria. LTA functions as an immune activator with characteristics very similar to lipopolysaccharide (LPS) from Gram-negative bacteria. LTA binds to CD14 and triggers activation predominantly via Toll-like receptor 2. Although LTA is internalized and traffics to the Golgi, the cellular activation in response to LTA occurs at the cell surface. |
| References | Hogg;S et al. journal of systematic bacteriology 1997; 47:62. Langevelde, P et al Antimicrob Agents Chemother 1998, 42: 3073. Langevelde; P et al. Antimicrob Agents Chemother 1999; 43: 2984. Triantafilou M et al. J Biol Chem 2004; 279: 40882. Henneke P et al. J Immunol 2005; 174: 6449 |
| Supplier | MONOSAN |
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