| Product Name | Mouse anti-Macrophages, clone MAC387 (Monoclonal) |
|---|---|
| Description | Mouse anti-Macrophages, clone MAC387 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MAC387 |
| Immunogen | Human monocytes. |
| Isotype | IgG1 |
| Reactivity | Marmoset, Hippopotamus, Bovine, Canine, Equine, Feline, Goat, Guinea Pig, Human, Mink, Porcine, Primate, Rabbit, Rat, Deer |
| Applications | IHC-Fr, FC, IHC-P |
| Working Dilutions | ,, |
| Diluent Buffer | PBS with 0.09% sodium azide |
| Concentration | 1.0 mg/ml |
| Storage | 2-8°C |
| Notes | Mouse anti Human macrophages, clone MAC387 recognizes the L1 or Calprotectin molecule, an intracytoplasmic antigen comprised of a 12 kDa alpha chain and a 14 kDa beta chain. Although originally described as binding to epitopes common to both the alpha and beta chains (Flavell et al. 1987) subsequent studies indicate that the antibody detects an epitope exclusively expressed on the beta chain (Goebeler et al. 1994) demonstrated by immunofluorescent and western blotting on both naturally expressing and transfected targets. In addition Mouse anti Human macrophages, clone MAC387 detects the beta chain in complex with the alpha.The antigen recognized by Mouse anti Human macrophages, clone MAC387 is expressed by granulocytes, monocytes and by tissue macrophages. Variable results have been reported for staining brain macrophages and microglia. The epitope recognized appears to be well conserved and the antibody is routinely used for the detection of myeloid cells in a wide range of species. |
| References | Obert, L. et al. (2002) Early pathogenesis of transmucosal Feline Immunodeficiency Virus infection. J. Virol. 76: 6311 - 6322 |
| Supplier | MONOSAN |
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