| Product Name | Mouse anti-MRP2 (ABCC2), clone M2II-12 (Monoclonal) |
|---|---|
| Description | Mouse anti-MRP2 (ABCC2), clone M2II-12 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | M2II-12 |
| Immunogen | MRP2 aa 860-950 |
| Isotype | IgG2a |
| Reactivity | Human |
| Applications | IHC-Fr, FC, ICC, WB |
| Working Dilutions | ICC (1:20-1:50),IHC-fr (1:20),,WB (1:50) |
| Diluent Buffer | supernatant with 0.7% BSA and 0.1% sodium azide |
| Concentration | 250 ug/ ml |
| Storage | 2-8°C |
| Notes | M2II-12 reacts with an internal epitope of cMOAT/MRP2, a 190-200 kD transmembrane protein known as the canalicular multi-organic anion transporter, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. cMOAT/MRP2 is closely related to the multidrug resistance related protein MRP, and cMOAT/MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. M2II-12 was raised against a bacterial fusion protein of cMOAB/M¬RP2, containing amino acids 860-950 of the protein. M2II-12 did not cross react with the human MDR1, MRP1, MRP3 and MRP5 gene products. |
| References | Paulusma et al. Science 1996; 271: 1126-1128. Kool et al. Cancer Res 1997; 57: 3537-3547 |
| Supplier | MONOSAN |
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