| Product Name | Mouse anti-MRP2 (ABCC2), clone M2III-5 (Monoclonal) |
|---|---|
| Description | Mouse anti-MRP2 (ABCC2), clone M2III-5 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | M2III-5 |
| Immunogen | 202-amino acid COOH terminal of rat Mrp2 |
| Isotype | IgG2b |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC-Fr, ICC, IHC-P, WB |
| Working Dilutions | ,,IHC-P (1:20), |
| Diluent Buffer | cell culture supernatant with 0.7% BSA and 0.1% sodium azide |
| Concentration | 250 ug/ ml |
| Storage | 2-8°C |
| Notes | The antibody reacts with an internal epitope of MRP2, a 190-200 kD transmembrane protein earlier known as the canalicular multi-organic anion transporter cMOAT, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. MRP2 is a member of the MRP family of multidrug resistance related proteins, and MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. M2III-5 was raised against a fusion protein of the bacterial maltose binding protein and rat Mrp2, containing the 202-amino acid COOH terminal end of the transporter protein. The Mab detects rat, mouse and human MRP2. M2III-5 does not cross-react with the human MDR1 P-gp, MRP1, MRP3 orMRP5 gene products. |
| References | Paulusma et al. Science 1996; 271: 1126-1128. Kool et al. Cancer Res 1997; 57: 3537-3547. Scheffer et al. Cancer Res 2000; 60: 5269-5277 |
| Supplier | MONOSAN |
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