Mouse anti-Multiple Myeloma Oncogene 1 (MUM-1), Clone EAU32 (monoclonal)
| Product Name | Mouse anti-Multiple Myeloma Oncogene 1 (MUM-1), Clone EAU32 (monoclonal) |
|---|---|
| Description | Mouse anti-Multiple Myeloma Oncogene 1 (MUM-1), Clone EAU32 (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | EAU32 |
| Immunogen | Prokaryotic recombinant protein corresponding to 313 amino acids of the human multiple myeloma oncogene 1 (MUM-1) molecule. |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:100) |
| Diluent Buffer | Tissue culture supernatant with sodium azide |
| Concentration | Greater than or equal to 263 mg/L |
| Storage | 2-8°C |
| Notes | The MUM-1 (multiple myeloma oncogene 1) gene was originally identified because of its involvement in the t(6:14) translocation observed in multiple myeloma, which causes the juxtaposition of the MUM-1 gene to the Ig heavy chain locus. MUM-1 is expressed in late plasma cell directed stages of B cell differentiation and in activated T cells, suggesting that MUM-1 may serve as a marker for lympho-hemopoietic neoplasms derived from these cells. The morphologic spectrum of MUM-1 expressing cells has been found to range from that of a centrocyte to that of a plasmablast/plasma cell. Consequently the histogenic value of MUM-1 may be to provide a marker to aid in the identification of the transition from BCL-6 positive (germinal center B cells) to CD138 positive (immunoblasts and plasma cells). |
| References | Bergsagel P and Kuehl W.Oncogene. 2001: 20(40);5611-5622. Iida S et al. Nature Genetics. 1997:17(2);226-230 |
| Supplier | MONOSAN |
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