| Product Name | Mouse anti-MVP/LRP, clone 1027 (Monoclonal) |
|---|---|
| Description | Mouse anti-MVP/LRP, clone 1027 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 1027 |
| Immunogen | affinity purified nuclear extract proteins |
| Isotype | IgM |
| Reactivity | Human |
| Applications | IHC-Fr, IF, WB |
| Working Dilutions | ,, |
| Diluent Buffer | PBS with 0.02% sodium azide |
| Concentration | 100 ug/ml |
| Storage | 2-8°C |
| Notes | 1027 Is specific for the major vault protein, a 104-kDa highly conserved protein interacting with estrogen receptor. It is one of a series of four mAbs which recognize different epitopes of the protein. Major vault proteins have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy. |
| References | Abbondanza, C. et al, J. Cell Biol. 141, 1301-1310 (1998). Den Boer, M.L. et al. Blood 91, 2092-2098 (1998) |
| Supplier | MONOSAN |
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