| Product Name | Mouse anti-Oct-3/4, clone N1NK (monoclonal) |
|---|---|
| Description | Mouse anti-Oct-3/4, clone N1NK (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | N1NK |
| Immunogen | Prokaryotic recombinant protein corresponding to 147 amino acids of the N-terminus of the human Oct-3/4 molecule. |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:100) |
| Diluent Buffer | Tissue culture supernatant with sodium azide |
| Concentration | Greater than or equal to 69 mg/L |
| Storage | 2-8°C |
| Notes | Oct-3/4 is a member of the POU homeodomain family of transcription factors, which is expressed by embryonic stem cells and germ cells. A critical amount of Oct-3/4 is required to maintain stem cell self replication. Down regulation of Oct-3/4 levels are associated with loss of pluripotency. Oct-3/4 has been proposed as a useful marker for germ cell tumors which exhibit features of pluripotentiality, including seminoma/dysgerminoma/germinoma and embryonal carcinoma, and establishing a germ cell origin for some metastatic tumors of uncertain primary origin. |
| References | Del Sordo R et al. Histology and histopathology. 2014; 29(1):101-106. Miettinen M et al. American Journal of Surgical Pathology. 2014; 38(3):410-420. Paine SML et al. Neuropathology and applied neurobiology. 2014; 40:544-550. Antic T et al. American Journal of Pathology. 2011; 136:872-880 |
| Supplier | MONOSAN |
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