| Product Name | Mouse anti-p53, clone Pab122 (Monoclonal) |
|---|---|
| Description | Mouse anti-p53, clone Pab122 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | Pab122 |
| Immunogen | SV40 infected 3T3 cells, 3T3/SV40 clone 4 (B4) |
| Isotype | IgG2b |
| Reactivity | Monkey, Canine, Human, Mouse, Rat |
| Applications | IHC-Fr, FC, IF |
| Working Dilutions | ,, |
| Diluent Buffer | PBS with 0.02% sodium azide |
| Concentration | 100 ug/ml |
| Storage | 2-8°C |
| Notes | PAb 122 binds to the C-terminus (aa370-378) of both wild type and mutated p53. When microinjected into nuclei, PAb 122 blocked re-entry into the S-phase of the cell cycle. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. |
| References | Gurney et al, J. Virol. 34(3): 752-763, (1980). Tack et al, J. Virol. 58(2): 635-45, (1986) |
| Supplier | MONOSAN |
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