Mouse anti-p80 (Anaplastic Lymphoma Kinase), clone 5A4 (monoclonal)
| Product Name | Mouse anti-p80 (Anaplastic Lymphoma Kinase), clone 5A4 (monoclonal) |
|---|---|
| Description | Mouse anti-p80 (Anaplastic Lymphoma Kinase), clone 5A4 (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 5A4 |
| Immunogen | Prokaryotic recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript (419-520αα). |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC-P |
| Diluent Buffer | Tissue culture supernatant with 15mM sodium azide |
| Concentration | Greater than or equal to 32 mg/L |
| Storage | 2-8°C |
| Notes | Anaplastic large cell lymphoma (ALCL) is usually composed of large pleomorphic cells which are reported to express CD30 antigen and epithelial membrane antigen (EMA). These tumor cells tend to occur in younger individuals and may be associated with cutaneous and extranodal involvement. A proportion of these cases contain a chromosomal translocation t(2;5) (p23;q35). This results in a hybrid gene encoding part of the nucleophosmin (NPM) gene joined to the cytoplasmic domain of the anaplastic lymphoma kinase (ALK) gene, giving rise to the protein, p80. Large cell lymphomas account for approximately 25% of all non-Hodgkin's lymphomas in children and young adults, of which one third carry the NPM-ALK gene translocation. |
| References | Liu A et al. Acta Histochemica et Cytochemica. 2004; 37(1):21-30. Li X-Q et al. Human Pathology. 2004; 35:711-721 |
| Supplier | MONOSAN |
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