| Product Name | Mouse anti-PD1, clone NAT105 |
|---|---|
| Description | Mouse anti-PD1, clone NAT105 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | NAT105 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC-P |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | Programmed death-1 (PD-1), also known as CD279, is a type-I transmembrane protein expressed on T-cells, B-cells, and monocytes during activation.1-2 PD-1 and its ligands (PD-L1 and PD-L2) function as an immune checkpoint pathway by regulating T-cell activation and autoimmunity.2 PD-1 labels follicular helper T-cells and is therefore a useful marker for angioimmunoblastic T-cell lymphoma.3-4 |
| References | Bolstad AI, et al. Arthritis Rheum. 2003 Jan;48(1):174-85. Dorfman DM, et al. Am J Surg Pathol. 2006 Jul;30(7):802-10. Hamanishi J, et al. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3360-5. Konishi J, et al. Clin Cancer Res. 2004 Aug 1;10(15):5094-100. Mataki N, et al. Am J Gastroenterol. 2007 Feb;102(2):302-12 |
| Supplier | MONOSAN |
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