| Product Name | Mouse anti-PLAP, clone NB-10 |
|---|---|
| Description | Mouse anti-PLAP, clone NB-10 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | NB-10 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG1-k |
| Reactivity | Human |
| Applications | IHC-P |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | Anti-PLAP antibody immunoreacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease. This antibody has shown cross-reaction with human intestinal alkaline phosphatase. |
| References | Paiva, J, et al. Am J Pathol 1984;111:156-165. Burke, AP, et al. Hum Path 1988;19:663-670. Wick, MR, et al. Hum Path 1987;18:946-954. Saad RS et al. Appl Immunohistochem Mol Morphol. 2003 Jun;11(2):107-12. Goldsmith JD et al. Am J Surg Pathol. 2002 Dec;26(12):1627-33 |
| Supplier | MONOSAN |
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