| Product Name | Mouse anti-Progesterone Receptor, clone 16 (monoclonal) |
|---|---|
| Description | Mouse anti-Progesterone Receptor, clone 16 (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 16 |
| Immunogen | Prokaryotic recombinant protein corresponding to the N-terminal region of the A form of the human progesterone receptor. |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:100-1:200) |
| Diluent Buffer | Tissue culture supernatant with sodium azide |
| Concentration | Greater than or equal to 324 mg/L |
| Storage | 2-8°C |
| Notes | The human progesterone receptor (PR) is expressed as two isoforms, PRA (94 kD) and PRB (114 kD), which function as ligand-activated transcription factors. These two isoforms are transcribed from distinct estrogen receptor (ER)-inducible promoters within a single copy PR gene. Clone 16 is specific for a region of the N-terminus of the A form of PR. The precise epitope has not been mapped but it reacts with both A and B forms of PR by Western blot but only with the A form by immunohistochemistry. This suggests that the epitope is inaccessible in the native folded B form of the protein. |
| References | Hungermann D et al. Journal of Pathology 2002; 198: 487–494 |
| Supplier | MONOSAN |
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