| Product Name | Mouse anti-Proteinase Inhibitor 9, clone PI9-17 (Monoclonal) |
|---|---|
| Description | Mouse anti-Proteinase Inhibitor 9, clone PI9-17 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | PI9-17 |
| Immunogen | fl recombinant PI9 |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC, WB |
| Working Dilutions | IHC (1:100), |
| Diluent Buffer | serumfree culture supernatant with 0.7% BSA and 0.1% sodium azide |
| Concentration | 250 ug/ml |
| Storage | 2-8°C |
| Notes | The human intracellular serpin proteinase inhibitor 9 (PI9) is the only human protein able to inhibit the activity of the serine protease granzyme B. Granzyme B is expressed by cytotoxic lymphocytes and induces rapid target cell apoptosis. PI9-17 Mab was selected after immunization with full length recombinant PI9 produced in Escherichia coli. No cross reactivity with other, homologous serpins (PI6, PI8 and PAI-2) was observed. |
| References | Bird CH et al. Mol.Cell.Biol 1998; 18: 6387. Bladergroen BA et al. J of Immunol 2001; 166: 3218-325. Bladergroen BA et al. Blood 2002; 99: 232-237 |
| Supplier | MONOSAN |
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