Mouse anti-Retinoblastoma Gene Protein, clone 13A10 (monoclonal)
| Product Name | Mouse anti-Retinoblastoma Gene Protein, clone 13A10 (monoclonal) |
|---|---|
| Description | Mouse anti-Retinoblastoma Gene Protein, clone 13A10 (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 13A10 |
| Immunogen | Recombinant prokaryotic protein corresponding to a portion of the N-terminal region of the retinoblastoma gene product. |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC-Fr, IHC-P, WB |
| Working Dilutions | IHC-P (1:25-1:50),,WB (1:250) |
| Diluent Buffer | Tissue culture supernatant with 15mM sodium azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | Retinoblastoma (Rb) is a rare tumor of the retina associated with mutations of chromosome 13. The nuclear phosphoprotein encoded by the Rb tumor suppressor gene is present in many cells and may indirectly regulate cell growth by activating the transcription factor ATF-2. Activation of ATF-2 initiates expression of TGF-beta2, which in turn inhibits transcription of genes affecting cell growth. Bilateral mutation of the Rb gene may potentially play a role in the development of a number of malignant tumors. |
| References | Jares P et al. Journal of Pathology. 182: 160-166 (1997). Karpeh MS et al. British Journal of Cancer. 72: 986-991 (1995). Stefanini M et al. Nature. 216: 173-174 (1967). Bartek J et al. Oncogene. 7: 101-108 (1992). Sanders BM et al. British Journal of Cancer. 60: 358-365 (1989) |
| Supplier | MONOSAN |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
