| Product Name | Mouse anti-Shigatoxin 1, clone 13C4 (Monoclonal) |
|---|---|
| Description | Mouse anti-Shigatoxin 1, clone 13C4 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 13C4 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG1 |
| Applications | ELISA, FA, WB |
| Working Dilutions | ,, |
| Diluent Buffer | PBS with 0.1% BSA and 0.02% sodium azide |
| Concentration | 100 ug/ ml |
| Storage | 2-8°C |
| Notes | The monoclonal antibody 13C4 recognizes the 1B subunit of Shiga-like toxin 1. Shiga-like toxins (SLTs), are also called Verotoxins. Enterohemorrhagic Escherichia coli (EHEC) strains which are primarily of serotypes 0157:H7, 026:H11 and O111:H8 have been incriminated as etiologic agents of hemorrhagic colitis and Hemolytic-uremic syndrome, a generalized disease characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. There are several distinct E.coli SLTs. SLT-I and SLT-II are produced by EHEC. SLT-I and Shiga toxin share;99% deduced amino acid sequence homology, whereas SLT-I and SLT-II share about 60% deduced amino acid sequence homology. SLT-I and SLT-II are antigenically distinct. The protein structure of the toxin consists of two domains: the A polypeptide that inhibits protein synthesis by targeting ribosomes, and the B polypeptide pentamer that binds to the eukaryotic cell receptor globotriaosylceramide (Gb3) leading to receptor-mediated endocytosis. |
| References | Strockbine; N et al. Infect Immun 1985; 50: 695. Smith, M et al Vaccine 2006, 24: 4122. Smith; M et al. Infect Immun 2006; 74: 6992 |
| Supplier | MONOSAN |
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