Mouse anti-SKP2 (S-Phase Kinase-Associated Protein 2), clone SKP2-8D9 (Monoclonal)
| Product Name | Mouse anti-SKP2 (S-Phase Kinase-Associated Protein 2), clone SKP2-8D9 (Monoclonal) |
|---|---|
| Description | Mouse anti-SKP2 (S-Phase Kinase-Associated Protein 2), clone SKP2-8D9 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | SKP2-8D9 |
| Immunogen | Recombinant, full-length human p45SKP2 protein |
| Isotype | IgG1k |
| Reactivity | Human, Primate |
| Applications | ELISA, ICC, IHC, IP, WB |
| Working Dilutions | ,,ICC/IF (1:250),, |
| Diluent Buffer | PBS with 0.1% sodium azide |
| Concentration | 0.5 mg/ml |
| Storage | 2-8°C |
| Notes | Skp2 (S-phase Kinase-associated Protein 2) belongs to the family of F-box proteins that interact with the Cyclin A-Cdk2 complex. Skp2 is essential for the G1-S transition in both transformed cells and diploid fibroblasts. Biochemical and genetic experiments have demonstrated that Skp2 is required for the ubiquitination and consequent degradation of p27 in cultured mammalian cells and in vitro reconstitution assays. In normal tissues, Skp2 is expressed in tonsil and placenta. |
| References | Li X et al. Eur.J of Histochem 2019. Bufalieri F et al. Nature comm. 2019. Chiarle R et al. Am J of Pathol 2002. Langner C et al. BJU int 2005. Yao F et al. Nature comm 2018 |
| Supplier | MONOSAN |
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