| Product Name | Mouse anti-SOX-11, clone MRQ-58 (Monoclonal) |
|---|---|
| Description | Mouse anti-SOX-11, clone MRQ-58 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MRQ-58 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:25-1:100) |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | SOX-11 which is a member of the SOX (SRY-related HMG-box) family is a transcription factor normally expressed in the developing human central nervous system and plays a role in embryonic cell determination. Studies show that SOX-11 can be used as a marker for mantle cell lymphoma (MCL). Mantle cell lymphoma (MCL) accounts for 5% to 10% of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of cyclin D1 (CCND1), an important regulator of the G1/S phase of the cell cycle, due to the specific translocation t(11;14)(q13;q32). |
| References | Hargrave, M et al. Dev Dyn 1997; 210:79-86. Zeng W, et al. Am J Surg Pathol 2012; 36:214-9. Salaverria, I et al. Haematologica 2006; 91:11-6. Fu, K et al. Blood 2005; 106:4315-21. Mozos, A et al. Haematologica 2009; 94:1555-1562 |
| Supplier | MONOSAN |
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