Mouse anti-Terminal Deoxynucleotidyl Transferase (Liquid Primary Antibody), clone SEN28 (monoclonal)
| Product Name | Mouse anti-Terminal Deoxynucleotidyl Transferase (Liquid Primary Antibody), clone SEN28 (monoclonal) |
|---|---|
| Description | Mouse anti-Terminal Deoxynucleotidyl Transferase (Liquid Primary Antibody), clone SEN28 (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | SEN28 |
| Immunogen | Prokaryotic recombinant protein corresponding to the amino terminal region of the terminal deoxynucleotidyl transferase molecule. |
| Isotype | IgG2a |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:100) |
| Diluent Buffer | Tissue culture supernatant with sodium azide |
| Concentration | Greater than or equal to 30 mg/L |
| Storage | 2-8°C |
| Notes | Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase of 58 kD located in the cell nucleus which catalyzes the polymerization of deoxynucleotides at the 3' hydroxyl ends of oligo or polydeoxynucleotide initiators and functions without a template. TdT is reported to be expressed in primitive T and B lymphocytes of the normal thymus and bone marrow. The identification of TdT-positive cell populations in primary and secondary lymphoid organs during maturation of the immune system is one area of interest but it is the reported occurrence of high levels of enzyme activity in white blood cells and bone marrow in certain leukemias which is of particular interest. |
| References | Tai YC and Peh SC. FSingapore Medical Journal. 2003; 44(5):250-255. Bollum FJ et al. Blood. 1979; 54(6):1203-1215 |
| Supplier | MONOSAN |
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