| Product Name | Mouse anti-Thyroid Peroxidase, clone AC25 (monoclonal) |
|---|---|
| Description | Mouse anti-Thyroid Peroxidase, clone AC25 (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | AC25 |
| Immunogen | Prokaryotic recombinant protein containing 105 amino acids corresponding to a portion of the N-terminus of the human thyroid peroxidase molecule. |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:80) |
| Diluent Buffer | Tissue culture supernatant with sodium azide |
| Concentration | Greater than or equal to 10.8 mg/L |
| Storage | 2-8°C |
| Notes | Thyroid peroxidase gene expression is under the regulation of thyroid stimulating hormone. In normal thyroid, expression of thyroid peroxidase (TPO) described immunohistochemically is reported to produce a diffuse, fine, granular cytoplasmic stain in all follicular cells. Some studies have shown qualitative, as well as quantitative differences in thyroid peroxidase expression in thyroid cancer compared to normal tissue. |
| References | Kimura S et al. Proceedings of the National Academy of Science USA 84: 5555-5559 (1987). De Micco C et al. Cancer 67(12): 3036–3041 (1991). Czarnocka B et al. Breast Journal Cancer 85(6): 875–880 (2001). Tanaka T et al. Journal of Pathology 179: 89–94 (1996) |
| Supplier | MONOSAN |
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