Mouse anti-Tumor Necrosis factor Alpha, clone 52B83 (Monoclonal)
| Product Name | Mouse anti-Tumor Necrosis factor Alpha, clone 52B83 (Monoclonal) |
|---|---|
| Description | Mouse anti-Tumor Necrosis factor Alpha, clone 52B83 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 52B83 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG1 |
| Reactivity | Guinea Pig, Human, Mouse, Primate |
| Applications | IHC-Fr, ELISA, FC, WB |
| Working Dilutions | ,,, |
| Diluent Buffer | PBS with 0.1% BSA and 0.02% sodium azide |
| Concentration | 100 ug/ ml |
| Storage | 2-8°C |
| Notes |
The monoclonal antibody 52B83 reacts with tumor necrosis factor alpha (TNF-alpha). TNF-alpha is a homotrimeric 17 kDa protein, that interacts with either one of the two types of TNF-receptors, termed I and II, leading to receptor cross-linking and signal transduction. The receptors differ strongly in their intra-cellular signaling pathways. TNF-alpha was originally described as a highly cytotoxic cytokine for tumor cells, it causes tumor necrosis in vivo and shows cytolytic activity against tumor cells in vitro. Furthermore,- TNF-alpha is found to be a central mediator in many inflammatory and immunological processes. It can be induced by various products of micro-organisms and by various cytokines leading to expression of a wide variety of- cytokines. The pro-inflammatory properties of- TNF-alpha play a central role in several auto-immune diseases such as rheumatoid arthritis and inhibition by neutralizing molecules have been shown to be beneficial in patients. |
| References | Bradding; P et al. Am J Respir Cell Mol Biol 1994; 10: 471. Bradding, P et al: Clin Exp Allergy 1995, 25: 406. Gerspach; J et al. Microsc Res Tech 2000; 50: 243. Laan van der N et al. Arch Dermatol Res 2001; 293: 226. Lee E et al. Ann Dermatol 2009; 21:345 |
| Supplier | MONOSAN |
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