| Product Name | Mouse anti-Tyrosinase, clone T311 (monoclonal) |
|---|---|
| Description | Mouse anti-Tyrosinase, clone T311 (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | T311 |
| Immunogen | Recombinant prokaryotic protein corresponding to the tyrosinase molecule. |
| Isotype | IgG2a |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:50) |
| Diluent Buffer | Tissue culture supernatant with sodium azide |
| Concentration | Greater than or equal to 89 mg/L |
| Storage | 2-8°C |
| Notes | The biosynthesis of melanin in melanocytes involves a family of enzymes, a key member of which is tyrosinase. Tyrosinase deficiency is associated with various forms of albinism and in particular oculocutaneous albinism. L-tyrosinase is the initial substrate for melanin biosynthesis and its conversion to dopaquinone is catalyzed by tyrosinase, whose expression is reported in melanocytes and melanomas. |
| References | Shidham VB et al. BMC Cancer. 2003; 3(1):15. Lohmann CM et al. American Journal of Surgical Pathology. 2002; 26(10):1351–1357. Clarkson KS et al. Journal of Clinical Pathology. 2001; 54(3):196–200. de Vries TJ et al. Journal of Pathology. 2001; 193(1):13–20. Jungbluth AA et al. Pathol Res Pract. 2000; 196(4):235–242 |
| Supplier | MONOSAN |
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