| Product Name | Mouse anti-Wilms' Tumor, clone WT49 (monoclonal) |
|---|---|
| Description | Mouse anti-Wilms' Tumor, clone WT49 (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | WT49 |
| Immunogen | A prokaryotic recombinant protein containing 1–181 amino acids of the N-terminal of the Wilms’ Tumor protein. |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:100) |
| Diluent Buffer | Tissue culture supernatant with sodium azide |
| Concentration | Greater than or equal to 44 mg/L |
| Storage | 2-8°C |
| Notes | Wilms' tumor protein (WT1) has a role in transcriptional regulation and is expressed in the kidney and a subset of hematopoietic cells. Alteration of transcription factor function is a common mechanism in oncogenesis. The WT1 protein contains a DNA binding domain and any deletions or point mutations of the WT1 gene which destroy this activity result in the development of the childhood nephroblastoma Wilms' tumor and Denys-Drash syndrome. The description of WT1 involvement in nephroblastoma is not clear. |
| References | Omeroglu A and Omeroglu G. Arch Pathol Lab Med. 2003; 127:e347-e348. Lee SB and Haber DA. Experimental Cell Research. 2001; 264:74-99 |
| Supplier | MONOSAN |
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