Mouse Mitochondrial import receptor subunit TOM34 (TOMM34) ELISA Kit
| Product Name | Mouse Mitochondrial import receptor subunit TOM34 (TOMM34) ELISA Kit |
|---|---|
| Description | TOMM34 is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. hTom34 is displayed on the surface of mitochondria and is resistant to extraction under alkaline conditions. Antibodies raised against hTom34 specifically inhibit in vitro import of the mitochondrial precursor protein preornithine transcarbamylase into mitochondria isolated from rat liver. Based on trypsin digestion experiments, the receptor has a large (27 kDa) C-terminal domain exposed to the cytosol. This assay has high sensitivity and excellent specificity for detection of Mouse TOMM34. No significant cross-reactivity or interference between Mouse TOMM34 and analogues was observed. |
| Synonyms | HTOM34P, TOM34, URCC3, mitochondrial import receptor subunit TOM34|outer mitochondrial membrane translocase (34kD) |
| Method | Sandwich ELISA |
| Detection Range | Request Information |
| Sensitivity | Request Information |
| Reactivity | Mouse |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | TOMM34 is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. hTom34 is displayed on the surface of mitochondria and is resistant to extraction under alkaline conditions. Antibodies raised against hTom34 specifically inhibit in vitro import of the mitochondrial precursor protein preornithine transcarbamylase into mitochondria isolated from rat liver. Based on trypsin digestion experiments, the receptor has a large (27 kDa) C-terminal domain exposed to the cytosol. |
| Supplier | Abebio |
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