| Product Name | MPO Monoclonal Antibody |
|---|---|
| Description | The MPO gene encodes myeloperoxidase,a lysosomal hemoprotein located in the azurophilic granules of polymorphonuclear (PMN) leukocytes and monocytes. In response to stimulation,MPO is activated into a transient intermediate with potent antimicrobial oxidizing abilities. The mRNA is translated into a single protein of 90 kDa,which displays enzymatic activity and undergoes proteolytic maturation into a heavy chain of 59 kDa and a light chain of 13.5 kDa; these subunits then dimerize into the mature tetramer and the mature MPO is a heterotetramer composed of two identical heavy chains and two identical light chains. The 24-kDa material had a map identical to that of 13.5 kDa subunit and represents a dimer of the 13.5 kDa subunit . Defects in MPO are the cause of myeloperoxidase deficiency (MPOD). It has 3 isoforms produced by alternative splicing. |
| Synonyms | MPO,myeloperoxidase |
| Host | Mouse |
| Clone | 9402 |
| Immunogen | Fusion protein of MPO |
| Isotype | IgA |
| Reactivity | Human |
| Applications | ELISA, IHC, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | P05164 |
| Background | The MPO gene encodes myeloperoxidase,a lysosomal hemoprotein located in the azurophilic granules of polymorphonuclear (PMN) leukocytes and monocytes. In response to stimulation,MPO is activated into a transient intermediate with potent antimicrobial oxidizing abilities. The mRNA is translated into a single protein of 90 kDa,which displays enzymatic activity and undergoes proteolytic maturation into a heavy chain of 59 kDa and a light chain of 13.5 kDa; these subunits then dimerize into the mature tetramer and the mature MPO is a heterotetramer composed of two identical heavy chains and two identical light chains. The 24-kDa material had a map identical to that of 13.5 kDa subunit and represents a dimer of the 13.5 kDa subunit . Defects in MPO are the cause of myeloperoxidase deficiency (MPOD). It has 3 isoforms produced by alternative splicing. |
| Supplier | Elabscience |
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