| Product Name | MUC2 Monoclonal Antibody |
|---|---|
| Description | Mucin 2 glycoprotein (MUC2) is a 520 kDa glycoprotein belonging to the superfamily of mucins. Mucins are high molecular weight glycoproteins produced by epithelial cells and can be divided into two families; secretory mucins and membrane bound mucins. MUC2 is a mucus-forming secreted mucin found in the cytoplasm of goblet cells in small intestine, colon, bronchus and salivary glands. MUC2 expression has been noted in primary gastrointestinal tract tumors of colonic, gastric and esophageal origin . MUC2 expression has also been found in goblet cells in colorectal carcinoma metastatic to the ovary, but not in primary mucinous ovarian adenocarcinoma. This antibody is a useful aid for classification of mucinous adenocarcinoma of gastrointestinal origin and intestinal metaplasia in Barrett's esophagus. Anti-MUC2 may also be a useful aid for classification of colon adenocarcinoma metastatic to the ovary.Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. |
| Synonyms | Mucin-2 ,MUC-2,Intestinal mucin-2 |
| Host | Mouse |
| Clone | PT0173 |
| Immunogen | Full length protein from eukaryotic expression system. |
| Isotype | IgG |
| Specificity | This antibody detects endogenous levels of MUC2 |
| Reactivity | Human |
| Applications | IHC |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Uniprot | Q02817 |
| Background | Mucin 2 glycoprotein (MUC2) is a 520 kDa glycoprotein belonging to the superfamily of mucins. Mucins are high molecular weight glycoproteins produced by epithelial cells and can be divided into two families; secretory mucins and membrane bound mucins. MUC2 is a mucus-forming secreted mucin found in the cytoplasm of goblet cells in small intestine, colon, bronchus and salivary glands. MUC2 expression has been noted in primary gastrointestinal tract tumors of colonic, gastric and esophageal origin . MUC2 expression has also been found in goblet cells in colorectal carcinoma metastatic to the ovary, but not in primary mucinous ovarian adenocarcinoma. This antibody is a useful aid for classification of mucinous adenocarcinoma of gastrointestinal origin and intestinal metaplasia in Barrett's esophagus. Anti-MUC2 may also be a useful aid for classification of colon adenocarcinoma metastatic to the ovary.Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. |
| Supplier | Elabscience |
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