| Product Name | Myr-tat-CBD3 |
|---|---|
| Description | Myr-tat-CBD3 is the N-terminal myristoylated version of TAT-CBD3 (PN-160), a peptide derived from the axonal collapsin response mediator protein 2 (CRMP-2). The myristoyl group allows insertion of myr-tat-CBD3 into membranes through hydrophobic interactions and myr-tat-CBD3 is membrane tethered, restricts the CaV2.2–CRMP2 interaction, blocks CaV2.2 trafficking, and strongly inhibits Ca2+ influx from primary sensory neurons. Intrathecal injection of myr-tat-CBD3 reduces carrageenan-induced inflammation and reverses paw incision–induced thermal and mechanical hypersensitivity without producing rewarding behaviour. |
| Synonyms | N-terminal myristoylated version of TAT-CBD3, CRMP-2), CaV2.2 -CRMP2 interaction, Myr-tat-CBD3, PP-180, axonal collapsin response mediator protein 2 |
| Molecular Weight | 3459.2 Da |
| Target | Protein-protein interactions,Calcium channels,Transient receptor potential (TRP) channels |
| Amino Acid Sequence | Myr-YGRKKRRQRRRARSRLAELRGVPRGL |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: Myristoyl at N terminal |
| References | Brittain et al (2011) Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex. Nature Med. 17(7) 822 www.ncbi.nlm.nih.gov/pmc/articles/PMC3219927/ Fischer et al (2014) Sustained relief of neuropathic pain by AAV-targeted expression of CBD3 peptide in rat dorsal root ganglion. Gene Ther. 21(1) 44 doi:10.1038/gt.2013.56 François-Moutal eta al (2015) A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors. Pain 156(7) 1247 doi: 10.1097/j.pain.0000000000000147 |
| Supplier | Isca Biochemicals Limited |
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