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|Product Name||NDP, 25-133aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSKTDSSFI MDSDPRRCMR HHYVDSISHP LYKCSSKMVL LARCEGHCSQ ASRSEPLVSF STVLKQPFRS SCHCCRPQTS KLKALRLRCS GGMRLTATYR YILSCHCEEC NS|
|Background||Norrin precursor, also known as NDP, is a secreted regulatory protein. It activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. This protein plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. It may be involved in a pathway that regulates neural cell differentiation and proliferation. Recombinant human NDP protein, fused to His-tag at N-terminus, was expressed in E.coli.|
|Concentration||0.5mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea|
|Intended Use||For Research Use Only|
|Molecular Weight||18.1 kDa (160aa)|
|NCBI Accession #||NP_000257|
|Purity||> 80% by SDS-PAGE|
|References||Luhmann U F., et al. (2005) Invest Pothalmol Vis Sci. 46:3372-3382.
Luhmann U F., et al. (2005) Genesis. 42:253-262
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Norrin, EVR2, FEVR, ND|
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