| Product Name | Neurokinin B (human, porcine) |
|---|---|
| Description |
Neurokinin B (human, porcine) is a tachykinin agonist peptide that shows preference for the NK3 receptor, with an EC50 of 1 nM. Neurokinin B (human, porcine) is an important endogenous neuropeptide and contributes to luteinizing hormone secretion, the estrous cycle, energy balance, dynamics of fetus in placenta, and contraction in uterine muscles of rat. Loss of function mutations in the genes encoding either neurokinin B or its receptor, NK3 result in hypogonadotropic hypogonadism, implicating NKB and NK3 as essential elements of the human reproductive axis. |
| Synonyms | NKB |
| Molecular Weight | 1210.43 Da |
| Target | Tachykinin receptors |
| Amino Acid Sequence | DMHDFFVGLM-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 86933-75-7 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C-terminal amide |
| References |
Laufer et al (1985) Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin. Proc.Natl.Acad.Sci.U.S.A. 82 7444 PMID: 2414777Rance et al (2010) Neurokinin B and the hypothalamic regulation of reproduction. Brain Res. 1364 116 PMID: 20800582Asmat et al (2020) Exogenous Neurokinin B Administration May Have a Strong Effect on Negative Feedback Loop of Hypothalamic Pituitary Thyroid Axis. Int. J. Peptide Res. Ther. 26 1259 https://doi.org/10.1007/s10989-019-09925-0 Related AreasAll peptides >All tachykinin receptor modulators >All endocrinology research categories >All neuroscience research categories > |
| Supplier | Isca Biochemicals Limited |
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