| Product Name | NFAT Inhibitor |
|---|---|
| Description |
NFAT inhibitor is a high affinity calcineurin binding peptide which acts as a selective inhibitor of the interaction of calcineurin with the transcription factor nuclear factor of activated T cells (NFAT), which it does without affecting calcineurin phosphatase activity or non-NFAT-mediated signaling. Activation of NFAT by calcineurin is a key step in T cell activation and accordingly NFAT inhibitor peptide blocks NFAT activation and NFAT dependent expression of endogenous T cell cytokine genes. Other cytokines that require calcineurin but not NFAT are not affected. NFAT inhibition by NFAT inhibitor peptide is an effective strategy to quench inflammation and hypertrophy. |
| Synonyms | VIVIT peptide, VIVIT-16 |
| Molecular Weight | 1684.06 Da |
| Target | Nuclear receptor modulators,Protein-protein interactions |
| Amino Acid Sequence | MAGPHPVIVITGPHEE |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 249537-73-3 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Aramburu et al (1999) Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science 285(5436) 2129 PMID: 10497131Yu et al (2007) Therapeutic potential of VIVIT, a selective peptide inhibitor of nuclear factor of activated T cells, in cardiovascular disorders. Cardiovasc Drug Rev. 25(2) 175 PMID: 17614939Ellert-Miklaszewska et al (2021) Delivery of the VIVIT Peptide to Human Glioma Cells to Interfere with Calcineurin-NFAT Signaling. Molecules 26(16) 4785 PMID: 34443374 Related dataAll peptides >All nuclear receptor modulators >All protein-protein interaction modulators >All immunology categories > |
| Supplier | Isca Biochemicals Limited |
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