| Product Name | Nociceptin |
|---|---|
| Description | Nociceptin/orphanin FQ (N/OFQ) is a 17-amino acid neuropeptide and an endogenous ligand for the nociceptin receptor (NOP, ORL-1). Nociceptin is derived from the prepronociceptin protein, as also are nocistatin and NocII, which inhibit N/OFQ receptor function. The name ‘nociceptin’ derives from the discovery that it can produce a pro-nociceptive response, and nociceptin acts as an anti-analgesic, counteracting the effect of pain-relievers. Nociceptin is widely distributed in the CNS and acts on numerous brain activities including pain sensation and fear. When administered to the spinal cord, nociceptin produces similar analgesic effects to the classical opioids. |
| Synonyms | Orphanin FQ |
| Molecular Weight | 1809 Da |
| Target | Nociceptin receptors |
| Amino Acid Sequence | FGGFTGARKSARKLANQ |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 170713-75-4 |
| Storage | We recommend storage desiccated, frozen and in the dark |
| Notes | Modifications: None |
| References |
Meunier et al (1995) Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 377 532 PMID: 7566152Reinscheid et al (1995) Orphanin FQ: a neuropeptide that activates an opioid like G protein coupled receptor. Science 270 792 PMID: 7481766 Henderson and McKnight (1997) The orphan opioid receptor and its endogenous ligand-nociceptin/orphanin FQ. TiPS 18 293 PMID: 9277133 Related areas All peptides >All nociceptin receptor modulators >All pain research categories >All neuroscience research categories > |
| Supplier | Isca Biochemicals Limited |
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