| Product Name | NT1-20 |
|---|---|
| Description |
NT1–20 is a tatylated membrane penetrating peptide derived from the N-terminus of the acid sensing ion channel 1a (ASIC1a), which can block ASIC1a binding receptor interacting protein kinase 1 (RIPK1) to its C terminus. ASIC1a mediates necroptosis via recruiting RIPK1, independent of its ion-conducting function, and though this mechanism NT1-20 can protect neurons against acidosis induced necroptosis in vitro. NT1-20 can also reduce neuronal damage in mouse models of ischemic stroke. |
| Synonyms | Peptide NT1-20 |
| Molecular Weight | 3655.22 Da |
| Target | Protein-protein interactions,Kinases,Acid sensing ion channels |
| Amino Acid Sequence | GRKKRRQRRRCMELKTEEEEVGGVQPVSIQA |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Wang et al (2020) Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis. Nat Commun. 11(1) 475 PMID: 31980622 Related areasAll cell penetrating peptides >All acid sensing ion channels >All protein-protein interaction modulators >All kinase modulators >All neuroscience categories > |
| Supplier | Isca Biochemicals Limited |
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