| Product Name | OAZ1 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to OAZ1 |
| Synonyms | Antizyme 1 antibody; Antizyme antibody; AZI antibody; MGC138338 antibody; OAZ 1 antibody; OAZ antibody; OAZ1 antibody; OAZ1_HUMAN antibody; ODC Az antibody; ODC-Az antibody; Ornithine decarboxylase antizyme 1 antibody; Ornithine decarboxylase antizyme antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant human Ornithine decarboxylase antizyme 1 protein (1-68AA) |
| Isotype | IgG |
| Target | OAZ1 |
| Reactivity | Human |
| Applications | ELISA, IHC |
| Form | Liquid |
| Diluent Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Uniprot | P54368 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to and targeting ODC1 for degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. |
| Supplier | Cusabio |
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