| Product Name | Orexin B (human) |
|---|---|
| Description | Orexin B (human) is an endogenous agonist peptide at orexin receptors with some selectivity for OX2 (with Ki values of 420 and 36 nM for OX1 and OX2 receptors respectively). Orexin B (human) stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Orexin B (human) is neuroprotective for dopaminergic neurons in animal models. |
| Synonyms | 205640-91-1, OX-020, OX020, Orexin B (human), RSGPPGLQGRLQRLLQASGNHAAGILTM, RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2 |
| Molecular Weight | 2899.37 Da |
| Target | Orexin receptors |
| Amino Acid Sequence | RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 205640-91-1 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C terminal amide |
| References |
Smart (1999) Orexins: a new family of neuropeptides. Br J Anaesth. 83(5) 695 PMID: 10690128Guerreiro et al (2015) The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine. Mol Pharmacol. 87(3) 525 PMID: 25552485Shingo and Sakurai (2020) Evolution of Orexin Neuropeptide System: Structure and Function. Frontiers in Neuroscience 14 691 PMID: 32754010 Related areas All peptides >All orexin receptor modulators >All neuroscience categories >All appetite regulation categories > |
| Supplier | Isca Biochemicals Limited |
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