| Product Name | P32/98 |
|---|---|
| Description | P32/98, also known as isoleucyl thiazolidide, is a potent and selective cell permeable inhibitor of dipeptidyl peptidase IV (DPP IV) with a Ki of 130 nM. P32/98 inhibition of DPP IV prevents degradation of both gastric inhibitory peptide (GIP) and Glucagon-like peptide-1, enhancing insulin secretion. P32/98 improves glucose tolerance, insulin sensitivity and beta-cell glucose responsiveness in diabetic fatty rats following oral administration. |
| Synonyms | Isoleucyl thiazolidide |
| Molecular Weight | 260.35 Da |
| Target | Dipeptidyl peptidase IV |
| Amino Acid Sequence | (2S,3S)-2-Amino-3-methyl-1-(thiazolidin-3-yl)pentan-1-one hemifumarate |
| Form | White solid |
| Purity | 98% by tlc |
| Cas Number | 136259-20-6 |
| Storage | Store desiccated, frozen and in the dark |
| References |
Pederson et al (1998) Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide. Diabetes 47 1253 PMID: 9703325Pospisilik et al (2002) Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral Ins sensitivity in the VDF Zucker rat. Diabetes 51 2677 PMID: 12196458Wagner et al (2016) Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation. Neuropeptides. 57 21 PMID: 26988064 Related areas All small molecules >All dipeptidyl peptidase IV modulators >All diabetes research categories > |
| Supplier | Isca Biochemicals Limited |
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