| Product Name | P5091 |
|---|---|
| Description | P5091 is a selective and inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 4.2 μM. P5091 displays little or no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases but does have some activity at USP47. P5091 induces elevated p53 and apoptosis in cancer cell lines and possesses antiangiogenic activity in vivo. |
| Synonyms | 882257-11-6, P5091, PI-100, PI100, USP7, antiangiogenic, apoptosis, ubiquitin-specific protease 7 |
| Molecular Weight | 348.22 Da |
| Target | Deubiquitinating enzymes |
| Amino Acid Sequence | 1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanone |
| Form | Off-white solid |
| Purity | >98% (HPLC) |
| Cas Number | 882257-11-6 |
| Storage | Store desiccated, frozen and in the dark |
| References |
Weinstock et al (2012) Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47. J.Med.Chem. 3 789 PMID: 24900381Chauhan et al (2012) A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell 22 345 PMID: 22975377 Related areas All small molecules >All deubiquitinating enzyme modulators >All cancer research categories > |
| Supplier | Isca Biochemicals Limited |
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