| Product Name | p63 Monoclonal Antibody |
|---|---|
| Description | P63 gene is a member of p53 gene family. This gene is located on chromosome 3q27-28, encoding more than 6 major isoforms which mainly involve in transcriptional kinase activity, death inducing activity (TAP63) and chromogenic inactivation activity. During the embryonic period, p63 protein is necessary for development of a variety of epithelial and organ. p63 can be expressed in myoepithelial cells, and its effect is better than SMA. While it is not expressed in myofibroblasts. Recent studies show that p63 is a marker for prostate basal cells, and is not expressed in most prostate tumors, the meaning of which is similar to that of 34bE12. Due to the nuclear positive staining of p63 and cytoplasm staining of P504S, so it is easy to judge the results if combines these two together.Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. |
| Synonyms | Tumor protein 63,p63,Chronic ulcerative stomatitis protein,CUSP,Keratinocyte transcription factor KET,Transformation-related protein 63,TP63,Tumor protein p73-like,p73L,p40,p51 |
| Host | Mouse |
| Clone | 1C2 |
| Immunogen | Full length protein from eukaryotic expression system. |
| Isotype | IgG |
| Specificity | This antibody detects endogenous levels of p63 |
| Reactivity | Human |
| Applications | IHC |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Uniprot | Q9H3D4 |
| Background | P63 gene is a member of p53 gene family. This gene is located on chromosome 3q27-28, encoding more than 6 major isoforms which mainly involve in transcriptional kinase activity, death inducing activity (TAP63) and chromogenic inactivation activity. During the embryonic period, p63 protein is necessary for development of a variety of epithelial and organ. p63 can be expressed in myoepithelial cells, and its effect is better than SMA. While it is not expressed in myofibroblasts. Recent studies show that p63 is a marker for prostate basal cells, and is not expressed in most prostate tumors, the meaning of which is similar to that of 34bE12. Due to the nuclear positive staining of p63 and cytoplasm staining of P504S, so it is easy to judge the results if combines these two together.Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. |
| Supplier | Elabscience |
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