| Product Name | PAMP 20 (human) |
|---|---|
| Description |
PAMP 20 (human) is an endogenous peptide agonist of Mas related GPR X2 (MRGPRX2) with an EC50 of 251 nM. PAMP 20, or proadrenomedullin N-terminal 20 peptide, is liberated from proadrenomedullin by proteolytic cleavage and is a potent hypotensive and catecholamine release inhibitory peptide. PAMP 20 (human) displays potent antimicrobial activity against standard bacterial strains, with a mechanism of action not involving the microbial cell membrane but instead targeting binding to bacterial DNA.
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| Synonyms | Proadrenomedullin N-terminal 20 peptide, PAMP (1-20) |
| Molecular Weight | 2460.87 Da |
| Target | Mas-related G protein-coupled receptors,Antibacterials |
| Amino Acid Sequence | ARLDVASEFRKKWNKWALSR-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 150238-87-2 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C-terminal amide |
| References |
Mahata et al (1998) Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors. Hypertension 32 907 PMID: 9822452Kamohara et al (2005) Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem Biophys Res Commun. 330(4) 1146 PMID: 15823563Ajish (2020) Proadrenomedullin N-terminal 20 peptide (PAMP) and its C-terminal 12-residue peptide, PAMP(9-20): Cell selectivity and antimicrobial mechanism. Biochem Biophys Res Commun. 527(3) 744 PMID: 32439180 Related areas All peptides >All mas-related G protein-coupled receptor modulators >All cardiovascular research categories >All antimicrobial agents > |
| Supplier | Isca Biochemicals Limited |
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