| Product Name | Pancreatic polypeptide (human) |
|---|---|
| Description |
Pancreatic polypeptide (human) is an endogenous high affinity agonist for the human NPY Y4 receptor, with a Ki of 0.056 nM. Pancreatic polypeptide (human) is produced and secreted by PP cells of the pancreas which are primarily located in the Islets of Langerhans and is a member of the family of peptides that includes peptide YY (PYY) and neuropeptide Y (NPY). Pancreatic polypeptide (human) is rapidly released after a meal and in humans remains elevated for 4-6 hours, with the vagus nerve being the major stimulator. Pancreatic polypeptide (human) causes a sustained decrease in both appetite and food intake. |
| Synonyms | Pancreatic polypeptide, PP |
| Molecular Weight | 4181.7 Da |
| Target | Neuropeptide Y receptors |
| Amino Acid Sequence | APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY-NH2 |
| Form | Freeze dried solid |
| Purity | >95% |
| Cas Number | 75976-10-2 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C-terminal amide |
| References |
Bard et al (1995) Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J.Biol.Chem. 270 26762 PMID: 7592911Batterham et al (2003) Pancreatic Polypeptide Reduces Appetite and Food Intake in Humans. J. Clin. Endocrinology Metabolism 88(8) 3989 PMID: 12915697Suzuki et al (2011) The gut hormones in appetite regulation. J Obes. 2011 528401 PMID: 21949903 Related areasAll peptides >All neuropeptide Y receptor modulators >All appetite regulation research categories > |
| Supplier | Isca Biochemicals Limited |
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